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Sunday, May 17, 2009

The Obama administration is moving toward demilitarizing a health problem.

Los Angele Times

May 16, 2009

The Obama administration is saying all the right things about the jumble of ineffective and vindictive laws, policies and practices that have made up this nation's so-called war on drugs.

Sunday, May 17, 2009

Wed, May 06, 2009 11:43 am

During a press conference on Tuesday, California governor Arnold Schwarzenegger said it’s “time for a debate” on the legalization of marijuana, particularly as a way to raise revenue in the cash-strapped Golden State.

Saturday, May 30, 2009
Publication Date (Web): August 6, 2008
Copyright © 2008 The American Chemical Society and American Society of Pharmacognosy

University of London.

Centro Ricerca Colture Industriali.

Abstract

Abstract Image

Marijuana (Cannabis sativa) has long been known to contain antibacterial cannabinoids, whose potential to address antibiotic resistance has not yet been investigated. All five major cannabinoids (cannabidiol (1b), cannabichromene (2), cannabigerol (3b), Δ9-tetrahydrocannabinol (4b), and cannabinol (5)) showed potent activity against a variety of methicillin-resistant Staphylococcus aureus (MRSA) strains of current clinical relevance. Activity was remarkably tolerant to the nature of the prenyl moiety, to its relative position compared to the n-pentyl moiety (abnormal cannabinoids), and to carboxylation of the resorcinyl moiety (pre-cannabinoids). Conversely, methylation and acetylation of the phenolic hydroxyls, esterification of the carboxylic group of pre-cannabinoids, and introduction of a second prenyl moiety were all detrimental for antibacterial activity. Taken together, these observations suggest that the prenyl moiety of cannabinoids serves mainly as a modulator of lipid affinity for the olivetol core, a per se poorly active antibacterial pharmacophore, while their high potency definitely suggests a specific, but yet elusive, mechanism of activity.

Saturday, May 16, 2009
Friday, May 15, 2009, 10:48

There is silence now where once loud huzzahs erupted from medical marijuana advocates in California after U.S.  Attorney General Eric Holder signaled this spring that federal authorities will no longer raid or interfere with medipot dispensaries in states where it is legal, so long as users abide by state law.

That’s because no big change has occurred since then in this state, whose voters via the 1996 Proposition 215 became the first in the nation to pass a state law legalizing medical use of marijuana.

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