Medical Research Journals & Articles

Wednesday, June 24, 2009

By National Organization for the Reform of Marijuana Laws

June 18, 2009

Uc_color_logo

LOS ANGELES --- A University of California researcher who has performed US-government sponsored studies of marijuana and lung function for over 30 years says that pot should be legal.

Sunday, May 31, 2009

Prof Mauro Maccarrone

April 20'th 2009

Endocannabinoids are derivatives of arachidonic acid (and of other poly-unsaturated fatty acids), that have been discovered approximately 15 years ago. Nowadays they are recognized as a new class of lipid signaling molecules, that play several central and peripheral roles.

Saturday, May 30, 2009
NORML | NORML Foundation

by Paul Armentano
Senior Policy Analyst

“Cannabinoids possess … anticancer activity [and may] possibly represent a new class of anti-cancer drugs that retard cancer growth, inhibit angiogenesis (the formation of new blood vessels) and the metastatic spreading of cancer cells." So concludes a comprehensive review published in the October 2005 issue of the scientific journal Mini-Reviews in Medicinal Chemistry.

Not familiar with the emerging body of research touting cannabis' ability to stave the spread of certain types of cancers? You're not alone.

Wednesday, May 27, 2009

August 6, 2008

University of San Diego

By Debra Kain

In a double-blind, placebo-controlled clinical trial to assess the impact of smoked medical cannabis, or marijuana, on the neuropathic pain associated with HIV, researchers at the University of California, San Diego School of Medicine found that reported pain relief was greater with cannabis than with a placebo.   The study, sponsored by the University of California Center for Medical Cannabis Research (CMCR) based at UC San Diego, will be published on line, August 6 in the journal Neuropsychopharmacology.

Monday, May 18, 2009

Via Normal

It is well established that alcohol increases accident risk.  Evidence of marijuana’s culpability in on-road driving accidents is much less convincing.

The term medical marijuana took on dramatic new meaning in February, 2000 when researchers in Madrid announced they had destroyed incurable brain tumors in rats by injecting them with THC, the active ingredient in cannabis.

Sunday, May 17, 2009
ASA RESEARCH UPDATE

Discovery Brings Total to Nearly 80

Researchers at the University of Mississippi detected nine new cannabinoids in a cannabis variety with a high dronabinol content. Two of the new cannabinoids display significant antibacterial properties. The new cannabinoids bring to nearly 80 the number of active constituent components in the cannabis plant with potential to bind to the two types of cannabinoid receptors found in humans.
Sunday, May 17, 2009

Update Understanding of Multiple Sclerosis

Atlanta:11/03/2008

Abstract (Summary) Cross-sectional, questionnaire-based survey provided during routine medical visits to consecutive patients in two university-based neurology clinics. The questionnaire was returned by 175 MS patients (94.1% response rate). The prevalence of ever-use and medicinal cannabis use were 43% and 17.1%, respectively. At the time of the survey, cannabis was being used by 12.5% (5/45) of recreational and 56.7% (17/30) of medical users (p <0.001). First cannabis consumption was after MS onset in 15 (50%) medicinal users. Clinical improvement was reported by 14 (46.7%) medicinal users.

Saturday, May 16, 2009

Journal Of Natural Products


Image: United States Fish and Wildlife Service

The list of medical uses for marijuana (Cannabis Sativa) continues to grow. The Journal of Natural Products recently published a paper outlining the newly isolated antibiotic effects of the class of molecules known as cannabanoids. This group includes the non-psychoactive cannabichromene, cannabigerol, and cannabidiol but also includes the well-known and definitely psychotropic tetrahydrocannabinol (THC).

Saturday, May 30, 2009
Publication Date (Web): August 6, 2008
Copyright © 2008 The American Chemical Society and American Society of Pharmacognosy

University of London.

Centro Ricerca Colture Industriali.

Abstract

Abstract Image

Marijuana (Cannabis sativa) has long been known to contain antibacterial cannabinoids, whose potential to address antibiotic resistance has not yet been investigated. All five major cannabinoids (cannabidiol (1b), cannabichromene (2), cannabigerol (3b), Δ9-tetrahydrocannabinol (4b), and cannabinol (5)) showed potent activity against a variety of methicillin-resistant Staphylococcus aureus (MRSA) strains of current clinical relevance. Activity was remarkably tolerant to the nature of the prenyl moiety, to its relative position compared to the n-pentyl moiety (abnormal cannabinoids), and to carboxylation of the resorcinyl moiety (pre-cannabinoids). Conversely, methylation and acetylation of the phenolic hydroxyls, esterification of the carboxylic group of pre-cannabinoids, and introduction of a second prenyl moiety were all detrimental for antibacterial activity. Taken together, these observations suggest that the prenyl moiety of cannabinoids serves mainly as a modulator of lipid affinity for the olivetol core, a per se poorly active antibacterial pharmacophore, while their high potency definitely suggests a specific, but yet elusive, mechanism of activity.

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